P-Well
90 capsules
P-Well -Prostate Support, Vascular Sexual Health, Urinary Tract Health*
Fortifies the overall health of the male reproductive system and provides advantages that make life better.*
P-Wells advanced prostate formula provides the following advantages for male reproductive health:
Prostate Support*
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Promotes healthy prostate size and function
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Helps manage oxidative stress and inflammation
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Supports healthy urination and bladder emptying
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Helps protect prostate cells
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Promotes healthy hormone metabolism in the prostate
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Helps maintain already healthy PSA levels
Sexual Vascular Health*
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Promotes better blood flow to the penis
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Helps improve sperm quality and motility
Urinary Tract Health*
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Supports healthy urinary flow
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Helps protect urinary tract surface and lining
Serious Science
Despite its playful name, the P-Well™ formula is based on serious science. Instead of using every potential ingredient that might have a positive effect, Biotest chose to include only the heavy hitters of prostate health, sexual function, and urinary tract health:
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Punicalagins from pomegranate whole fruit extract
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Lycopene from natural tomato fruit extract
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Cranberry whole fruit 50:1 concentrate
Here's a brief rundown of what each P-Well™ ingredient offers:
Punicalagins from pomegranate whole fruit extract
Punicalagins are tannins found in pomegranate and pomegranate juice. You might not have heard of them before, but punicalagins and their metabolites, ellagic acid and urolithins, are largely responsible for pomegranate's reputation of being a super-healthy fruit with almost unparalleled qualities.
While it's an incredibly potent antioxidant, about three times greater than green tea or red wine, pomegranate directly benefits the male reproductive system in these powerful ways:
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Helps manage reproductive inflammation
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Promotes healthy prostate size and function
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Supports healthy hormone metabolism in the prostate
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Helps maintains already healthy PSA levels
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Promotes better blood flow to the penis
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Supports healthy urinary flow
Lycopene from natural tomato fruit extract
Lycopene is a red carotenoid pigment that gives tomatoes, watermelons, and pink grapefruit their characteristic colour. Lycopene has over 2,000 peer-reviewed studies dedicated to it, making it one of the most studied plant chemicals ever.
Even though its health-promoting effects are diverse, lycopene specifically fortifies male reproductive health in the following unique ways:
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Helps protect prostate cells from oxidative stress
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Promotes improved sperm quality and motility
Cranberry whole fruit 50:1 concentrate
Cranberries contain a variety of plant chemicals with positive effects on the urinary tract. This is especially true with a strong cranberry concentrate like that found in the P-Well™ formula.
Multiple studies show cranberry, especially cranberry concentrate, sustains the health of the muscles that control the bladder and provides the following important advantages for the urinary tract:
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Promotes healthy urination and bladder emptying
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Helps protect urinary tract surface and lining
Tangible Benefits, Better Health, Better Life
Perhaps most important, the P-Well™ formula fortifies the overall health of the prostate and provides advantages that make life better.
References
Pomegranate References
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Sharma P et al. Pomegranate for Prevention and Treatment of Cancer: An Update. Molecules. 24 January 2017.
Summary: This review summarizes preclinical and clinical studies highlighting the role of pomegranate in prevention and treatment of skin, breast, prostate, lung, and colon cancers.
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Vicinanza R et al. Pomegranate Juice Metabolites, Ellagic Acid and Urolithin A, Synergistically Inhibit Androgen-Independent Prostate Cancer Cell Growth via Distinct Effects on Cell Cycle Control and Apoptosis. Evidence Based Complementary and Alternative Medicine. 19 February 2013.
Summary: This study describes how ellagitannins (ETs) from pomegranate juice (PJ) are bioactive polyphenols with chemopreventive potential against prostate cancer (PCa).
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Wang L et al. Cellular and molecular mechanisms of pomegranate juice-induced anti-metastatic effect on prostate cancer cells. Integr Biol. 2011 May 19.
Summary: This study demonstrates how, in addition to causing cell death of hormone-refractory prostate cancer cells, pomegranate also increases cell adhesion and decreases cell migration of the cells that do not die.
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Chaves FM et al. Pomegranate Juice and Peel Extracts are Able to Inhibit Proliferation, Migration and Colony Formation of Prostate Cancer Cell Lines and Modulate the Akt/mTOR/S6K Signaling Pathway. Plant Foods Hum Nutr. 2020 March;75(1):54-62.
Summary: This study presents evidence that both juice and isolated peel extracts from pomegranate fruit have important anti-cancer effects against prostate cancer cells, modulating the mTOR/S6K signaling pathway.
Lycopene References
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Chen P et al. Lycopene and Risk of Prostate Cancer. A Systematic Review and Meta-Analysis. Medicine (Baltimore). 2015 Aug;94(33): 31260.
Summary: This study demonstrates that higher lycopene consumption/circulating concentration is associated with a lower risk of PCa.
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Lane JA et al. ProDiet: A Phase II Randomized Placebo-controlled Trial of Green Tea Catechins and Lycopene in Men at Increased Risk of Prostate Cancer. Cancer Pres Res. 2018 Nov;11(1): 687-696.
Summary: This study aimed to establish the feasibility and acceptability of dietary modification in men at increased risk of prostate cancer. Men were invited with a PSA level of 2.0-2.95 ng/mL or 3.0-19.95 ng/mL with negative prostate biopsies. Randomization (3 × 3 factorial design) to daily green tea and lycopene: green tea drink (3 cups, unblinded) or capsules [blinded, 600 mg flavan-3-ol ()-epigallocatechin-3-gallate (EGCG) or placebo] and lycopene-rich foods (unblinded) or capsules (blinded, 15 mg lycopene or placebo) for 6 months. All interventions were acceptable and well tolerated although men preferred the capsules. Dietary prevention is acceptable to men at risk of prostate cancer. This intervention trial demonstrates that a chemoprevention clinical trial is feasible.
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Wang Y et al. Lycopene, tomato products and prostate cancer-specific mortality among men diagnosed with nonmetastatic prostate cancer in the Cancer Prevention Study II Nutrition Cohort. Int J Cancer. 2016 June 15;138 (12):2846-55.
Summary: Among men with high-risk cancers (T3-T4 or Gleason score 8-10, or nodal involvement), consistently reporting lycopene intake ≥ median on both post diagnosis surveys was associated with lower prostate-cancer specific mortality.
Cranberry References
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Vidlar A et al. The effectiveness of dried cranberries ( Vaccinium macrocarpon) in men with lower urinary tract symptoms. Brit J Nutr, 2010 Oct;104(8):118-9.
Summary: The objective of this study was to evaluate the efficacy and tolerability of cranberry (Vaccinium macrocarpon) powder in men at risk of prostate disease with lower urinary tract symptoms (LUTS), elevated prostate-specific antigen (PSA), negative prostate biopsy and clinically confirmed chronic non-bacterial prostatitis. The results of the present trial are the first firm evidence that cranberries may ameliorate LUTS, independent of benign prostatic hyperplasia or C-reactive protein level.
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Wang CH et al. Cranberry-Containing Products for Prevention of Urinary Tract Infections in Susceptible Populations: A Systematic Review and Meta-analysis of Randomized Controlled Trials. Arch Intern Med. 2012;172(13):988-996.
Summary: The results of the present meta-analysis support that consumption of cranberry-containing products may protect against UTIs in certain populations.
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Luis A et al. Can Cranberries Contribute to Reduce the Incidence of Urinary Tract Infections? A Systematic Review with Meta-Analysis and Trial Sequential Analysis of Clinical Trials. The Journal of Urology. Volume 3 198. Issue 3. September 2017. Pages 614-621.
Summary: The findings clearly showed the potential use of cranberries for the clinical condition of urinary tract infection. Cranberry products significantly reduced the incidence of urinary tract infections as indicated by the weighted risk ratio (0.6750, 95% CI 0.5516–0.7965, p < 0.0001). The results could be used by physicians to recommend cranberry ingestion to decrease the incidence of urinary tract infections, particularly in individuals with recurrent urinary tract infections. This would also reduce the administration of antibiotics, which could be beneficial since antibiotics can lead to the worldwide emergence of antibiotic resistant microorganisms.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Disclaimer: Individual results may vary.
