Rez-V...

• Contains 6 times as much pure resveratrol as many store-bought brands.*
• Protects testosterone and naturally stimulates testosterone production.*
• Keeps estrogen levels under control.*
• Protects against man-made environmental estrogens that lower testosterone.*
• Promotes fat loss.*
• Promotes blood vessel, cardiovascular, and joint health.*
• Exhibits prostate protectant effects, liver protective effects, and anti-aging effects.*

Live Better and Look Better. Control Estrogen*

Men who lift weights or play sports want a naturally high level of testosterone. At the very least, they want their testosterone levels to be normal, and they definitely don't want their natural levels to drop to "low-normal" or below.

Having "high-normal" testosterone means that muscle gains come faster, fat loss comes easier, sports performance stays high, and you generally feel, well, good. Low testosterone has been linked to fatigue and even issues in the bedroom.

Trouble is, some testosterone converts into estrogen in a process called aromatization, which takes place mostly in fat tissue and muscle. Too much estrogen can cause an increase in body fat, a reduction of muscle mass, and even a decrease in strength.

To make things worse, increased levels of estradiol can then enter the bloodstream and travel to the pituitary and signal it to stop producing the hormone that prompts the male body to produce testosterone.

Furthermore, a lot of progressive scientists and doctors now believe that estrogen plays more of a negative role in prostate health than the other testosterone metabolite that gets most of the blame — DHT.

So while men need some estrogen to maintain the health of blood vessels, if it gets out of control it can cause a host problems.

Man-Made Estrogens Are Everywhere

Many chemicals in the environment mimic estrogen. These phony estrogens (xenoestrogens) exist in plastic bottles and bowls, air fresheners, pesticides, detergents, even toothpaste. They're everywhere, and far too many find their way into your body every single day.

Enter Resveratrol

Resveratrol is a natural polyphenol found in small amounts in grapes and mulberries. It's also one of the main reasons why a little red wine may be healthy for you. Resveratrol has been shown to have a host of health benefits, but the one you should be most interested in has to do with estrogen.*

Resveratrol acts as a potent estrogen antagonist (while also acting as an agonist in some tissues, similar to the drugs clomiphene and tamoxifen). In higher concentrations, it acts as an aromatase inhibitor. That means it stops the body from whittling away at your testosterone.*

If a substance stops testosterone from being converted to estrogen or estradiol, it not only prevents the nasty effects of estrogen (loss of muscle and accrual of body fat), but it increases your level of testosterone, leading to additional strength and muscle.*

The aromatase inhibition occurs through two mechanisms: reducing the expression of aromatase, as well as binding to the enzyme and preventing it from doing its dirty work. And, unlike conventional aromatase inhibitors, resveratrol doesn't cause a decline in blood vessel function. In fact, it seems to improve it.*

Resveratrol also occupies the receptor sites, or biological "parking lots," so that xenoestrogens can't "park" in their spots. This helps you fight off those man-made estrogens that can lower testosterone.*

Fat Loss and Other Health Benefits

Calorie deprivation activates a protein called SIRT1. Activation of this protein inhibits PPAR-gamma activity and this causes your body to burn fat. Resveratrol activates this very same SIRT1 protein, without you needing to diet excessively.*

Additionally, an overwhelming amount of literature on resveratrol has demonstrated potent cardiovascular benefits, anti-aging effects, and positive neurological effects. Many of these benefits stem from anti-oxidative and anti-inflammatory effects as well as gene modulation.*

Optimal Rez-V Dosing

Rez-V contains the purest, highest-grade of resveratrol possible. It's best to take one large dose of resveratrol, instead of several smaller doses, because of the way it's metabolized.*

A three-capsule dose of Rez-V contains 600 mg of pure resveratrol, the amount you need to get the maximal effects. That's 6 times as much as many other brands.*

References

1. Juan ME, et al. "trans-Resveratrol, a natural antioxidant from grapes, Increases sperm output in healthy rats." J Nutr. 2005 Apr;135(4):757-60.
2. Bhat KP, et al. "Estrogenic and antiestrogenic properties of resveratrol in mammary tumor models." Cancer Res. 2001 Oct 15;61(20):7456-63.
3. Henry LA, Witt DM. "Resveratrol: phytoestrogen effects on reproductive physiology and behavior in female rats." Horm Behav. 2002 Mar;41(2):220-8.
4. Matsumura A, Ghosh A, Pope GS, Darbre PD. "Comparative study of oestrogenic properties of eight phytoestrogens in MCF7 human breast cancer cells." J Steroid Biochem Mol Biol. 2005 Apr;94(5):431-43.
5. Bowers JL, et al. "Resveratrol acts as a mixed agonist/antagonist for estrogen receptors alpha and beta." Endocrinology. 2000 Oct;141(10):3657-67.
6. Lu R, Serrero G. "Resveratrol, a natural product derived from grape, exhibits antiestrogenic activity and inhibits the growth of human breast cancer cells." J Cell Physiol. 1999 Jun;179(3):297-304.
7. Turner RT, et al. "Is resveratrol an estrogen agonist in growing rats?" Endocrinology. 1999 Jan;140(1):50-4.
8. Bhat KP, Pezzuto JM. "Resveratrol exhibits cytostatic and antiestrogenic properties with human endometrial adenocarcinoma (Ishikawa) cells." Cancer Res. 2001 Aug 15;61(16):6137-44.
9. Wang Y, et al. "The Red Wine Polyphenol Resveratrol Displays BI-Level Inhibition on Aromatase in Breast Cancer Cells." Toxicol Sci. 2006 Apr 11; E-Published Ahead of Print
10. Wallerath T, et al. "A blend of polyphenolic compounds explains the stimulatory effect of red wine on human endothelial NO synthase." Nitric Oxide. 2005 Mar;12(2):97-104.
11. Lekakis J, et al. "Polyphenolic compounds from red grapes acutely improve endothelial function in patients with coronary heart disease." Eur J Cardiovasc Prev Rehabil. 2005 Dec;12(6):596-600.
12. Buluc M, Demirel-Yilmaz E. "Resveratrol decreases calcium sensitivity of vascular smooth muscle and enhances cytosolic calcium increase in endothelium." Vascul Pharmacol. 2006 Apr;44(4):231-7.
13. Labinskyy N, et al. "Vascular dysfunction in aging: potential effects of resveratrol, an anti-inflammatory phytoestrogen." Curr Med Chem. 2006;13(9):989-96.
14. Bhat KPL, et al. "Biological effects of resveratrol." Antioxid Redox Signal. 2001 Dec;3(6):1041-64.
15. Bradamante S, et al. "Cardiovascular protective effects of resveratrol." Cardiovasc Drug Rev. 2004 Fall;22(3):169-88.
16. de la Lastra CA & Villegas I. "Resveratrol as an anti-inflammatory and anti-aging agent: mechanisms and clinical implications." Mol Nutr Food Res. 2005 May;49(5):405-30.
17. Delmas D, Jannin B, Latruffe N. "Resveratrol: preventing properties against vascular alterations and ageing." Mol Nutr Food Res. 2005 May;49(5):377-95.
18. Valenzano DR, et al. "Resveratrol prolongs lifespan and retards the onset of age-related markers in a short-lived vertebrate." Curr Biol. 2006 Feb 7;16(3):296-300.
19. Marambaud P, Zhao H, Davies P. "Resveratrol promotes clearance of Alzheimer's disease amyloid-beta peptides." J. Biol. Chem 2005 Nov;280(45): 37377-37382
20. Molnar V, Garai J. "Plant-derived anti-inflammatory compounds affect MIF tautomerase activity." Int Immunopharmacol. 2005 May;5(5):849-56.
21. Elmali N, et al. "Effect of resveratrol in experimental osteoarthritis in rabbits." Inflamm Res. 2005 Apr;54(4):158-62.
22. Kopp P. "Resveratrol, a phytoestrogen found in red wine. A possible explanation for the conundrum of the 'French paradox'?" Eur J Endocrinol. 1998 Jun;138(6):619-20.
23. Constant, J. "Alcohol, ischemic heart disease, and the French paradox." Coron. Artery Dis. 1997; 8:645 – 649.
24. Das, D K, et al. "Cardioprotection of red wine: role of polyphenolic antioxidants." Drugs Exp Clin Res. 1999;25(2-3):115-20.
25. Soleas GJ, Diamandis EP, Goldberg DM. "The world of resveratrol." Adv Exp Med Biol. 2001;492:159-82.
26. Wyke SM, Tisdale MJ. "Induction of protein degradation in skeletal muscle by a phorbol ester involves upregulation of the ubiquitin-proteasome proteolytic pathway." 2006 May;78(25):2898-2910
27. Tisdale MJ. "The ubiquitin-proteasome pathway as a therapeutic target for muscle wasting." J Support Oncol. 2005 May-Jun;3(3):209-17.
28. Wyke SM, Russell ST, Tisdale MJ. "Induction of proteasome expression in skeletal muscle is attenuated by inhibitors of NF-kappaB activation." Br J Cancer. 2004 Nov 1;91(9):1742-50.
29. Borra MT, Smith BC, Denu JM. "Mechanism of human SIRT1 activation by resveratrol." J Biol Chem. 2005 Apr 29;280(17):17187-95.
30. Picard F, et al. "Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma." Nature. 2004 Jun 17;429(6993):771-6.
31. Wolf G. "Calorie restriction increases life span: a molecular mechanism." Nutr Rev. 2006 Feb;64(2 Pt 1):89-92.
32. Ingram DK, et al. "Calorie restriction mimetics: an emerging research field." Aging Cell. 2006 Apr;5(2):97-108.
33. Roth GS, Lane MA, Ingram DK. "Caloric restriction mimetics: the next phase." Ann N Y Acad Sci. 2005 Dec;1057:365-71.
34. Tian WX. "Inhibition of fatty acid synthase by polyphenols." Curr Med Chem. 2006;13(8):967-77.
35. Kasdallah-Grissa A, et al. "Protective effect of resveratrol on ethanol-induced lipid peroxidation in rats." Alcohol Alcohol. 2006 May-Jun;41(3):236-9
36. Sener G, et al. "Protective effects of resveratrol against acetaminophen-induced toxicity in mice." Hepatol Res. 2006 Apr 1; E-Published Ahead of Print
37. Docherty JJ, et al. "Effect of resveratrol on herpes simplex virus vaginal infection in the mouse." Antiviral Res. 2005 Sep;67(3):155-62.
38. Jung HJ, et al. "Fungicidal effect of resveratrol on human infectious fungi." Arch Pharm Res. 2005 May;28(5):557-60.
39. Palamara AT, et al. "Inhibition of influenza A virus replication by resveratrol." J Infect Dis. 2005 May 15;191(10):1719-29.
40. Yoo KM, et al. "Potent Inhibitory Effects of Resveratrol Derivatives on Progression of Prostate Cancer Cells." Arch Pharm (Weinheim). 2006 Apr 18;339(5):238-241
41. Jones SB, et al. "Resveratrol-induced gene expression profiles in human prostate cancer cells." Cancer Epidemiol Biomarkers Prev. 2005 Mar;14(3):596-604.
42. Scifo C, et al. "Resveratrol and propolis as necrosis or apoptosis inducers in human prostate carcinoma cells." Oncol Res. 2004;14(9):415-26.
43. Kim YA, et al. "Antiproliferative effect of resveratrol in human prostate carcinoma cells." J Med Food. 2003 Winter;6(4):273-80.
44. Stewart JR, Artime MC, O'Brian CA. "Resveratrol: a candidate nutritional substance for prostate cancer prevention." J Nutr. 2003 Jul;133(7 Suppl):2440S-2443S.
45. Ratan HL, et al. "Resveratrol – a prostate cancer chemopreventive agent?" Urol Oncol. 2002 Nov-Dec;7(6):223-7.
46. Aggarwal BB, et al. "Role of resveratrol in prevention and therapy of cancer: preclinical and clinical studies." Anticancer Res. 2004 Sep-Oct;24(5A):2783-840.
47. Aziz MH, Kumar R, Ahmad N. "Cancer chemoprevention by resveratrol: in vitro and in vivo studies and the underlying mechanisms (review)." Int J Oncol. 2003 Jul;23(1):17-28.
48. Delmas D, et al. "Resveratrol as a chemopreventive agent: a promising molecule for fighting cancer." Curr Drug Targets. 2006 Apr;7(4):423-42.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Disclaimer: Individual results may vary.